Effect of Ammonium 5-Tungsto-2-Antimoniate on Encephalomyocarditis and Vesicular Stomatitis Virus Infections in Mice

The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.

Inflammasomes are cytosolic protein complexes that regulate caspase-1 activation and the secretion of interleukin-1β (IL-1β) and IL-18. Several different inflammasome complexes have been identified, but the NLRP3 inflammasome is particularly notable because of its central role in diseases of inflammation. Recent work has demonstrated an essential role for the NLRP3 inflammasome in host defense ...

Pseudotypes of vesicular stomatitis virus with the mixed coat of reticuloendotheliosis virus and vesicular stomatitis virus.

Vesicular stomatitis virus (VSV) forms pseudotypes with envelope components of reticuloendotheliosis virus (REV). The VSV pseudotype possesses the limited host range and antigenic properties of REV. Approximately 70% of the VSV, Indiana serotype, and 45% of VSV, New Jersey serotype, produced from the REV strain T-transformed chicken bone marrow cells contain mixed envelope components of both VS...

Vesicular Stomatitis Virus

Defective particles were the major product after undiluted passage of certain temperature-sensitive (ts) mutants of the Indiana C strain of vesicular stomatitis virus in BHK-21 cells at the permissive temperature (31 C). Essentially homogeneous preparations of defective particles were obtained with the wild-type and individual ts mutants. The defective particles associated with some of the ts m...

Interferon production in mice by vesicular stomatitis virus.

Production of Vesicular Stomatitis Virus

In recent years a major thrust in immunology has been to clarify the morphological, surface, and functional properties of the complex populations comprising the lymphoid cell series. At the core of the problem is the mechanism of lymphocyte "activation," the process by which specific antigens or nonspecific agents stimulate resting lymphocytes to transform morphologically (1-5) and to exhibit a...